Endocrine Abstracts

Bone loss in chronic autoimmune inflammatory diseases is a major clinical problem. Inflammation-mediated osteoposis (IMO) is the first animal model of generalized osteoporosis resulting from inflammation. The P2×7 receptor, an ATP-gated ion-channel, is primarily expressed on immune and bone cells. ATP is now seen as a novel inflammatory mediator, with P2×7 as main target of the pro-inflammatory activity. The P2×7-receptor has a regulatory role in bone formation ...

The calcium receptor (CASR) serves as one of the main regulators of the calcium homeostasis. CASR is expressed in among other tissues parathyroid chief cells and kidney tubule cells. It has been hypothesized that CASR gene variations are responsible for low circulating calcium levels together with hypercalciuria and thereby increased risk of kidney stones. The CASR gene polymorphism A986S has been shown associated to elevated serum calcium levels in vivo<...

Background and aim: The dual-release hydrocortisone Plenadren® has shown promising results of improved cardiovascular and metabolic profiles after treatment of adrenal insufficiency, possibly due to an improved circadian profile of cortisol, but results are ambiguous. Aim: To further investigate the potential effect of dual-release hydrocortisone on the metabolic profile as compared to conventional hydrocortisone in patients with secondary adrenal i...